Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist

Authors

Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran

Abstract

Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-
phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-
3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all four
labeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence from
Ba14CO3.

Keywords


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