Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

Authors

1 Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz 6134968875, Iran

2 Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad, 91775-1436, Iran

3 Department of Chemistry, School of Sciences, Islamic Azad University, Ahvaz Branch, Ahvaz, 6134968875, Iran

4 Physiology Research Center and Department Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran

Abstract

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with
dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-
e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with
secondary amines in boiling ethanol to afford the related 7-amino derivatives.

Keywords


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