A convenient method for 14C-labeling of N-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as CCK-A antagonist

Authors

Nuclear science Research School, Nuclear Science & Technology Research Institute

Abstract

N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-
[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a key
synthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in the
presence of tetrakis (triphenylphosphine) palladium.

Keywords


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