Electropolymerization of 4-aminobenzoic acid containing nano-Au deposited on carbon paste electrode for determination of acetaminophen

Authors

Department of Chemistry, Shanghai University, Shanghai, P. R. China

Abstract

The conducting polymer films have been widely applied in the field of electrochemistry owing to their good
stability, permselectivity, unique physical and chemical properties. A novel nano-Au/poly (4-aminobenzoic
acid) (PABA) film modified carbon paste electrode was fabricated for sensitive detection of acetaminophen
in this paper. The PABA film and nano-Au/PABA film were characterized by scanning electron microscope.
The nano-Au/PABA film exhibited obviously catalytic performance to the determination of acetaminophen
with a high sensitivity and a wide linear range. Under optimum conditions (pH, the concentration of 4-
aminobenzoic acid, electro-polymerization cycles), linearity between the oxidation peak current and the
acetaminophen concentration was obtained in the range of 1.0 × 10–7 – 8.0 × 10–5 mol L-1 with a detection
limit of 8.0 × 10–8 mol L-1 (S/N = 3). In addition, the nano-Au/PABA film modified electrode was
successfully employed to determine the acetaminophen in commercial drugs, and this work has shed some
doubt on the redox mechanism of acetaminophen at the sensor.

Keywords


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