Synthesis, Anti-bacterial and Anti-fungal evaluation of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4 yl)acrylamide


Industrial Chemistry Department, Science College, Vallabh Vidyangar, Gujarat, India


The Series of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide compounds were prepared by
reaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by Claisen-Schmidt Condensation reaction
with different aromatic aldehydes. The structures of new compounds were confirmed by IR, 1H-NMR and
13C-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with the
standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity
compared to standard drugs.


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